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Quinine CAS 130-95-0 Raw Steroid Powders Antimalarial Muscle Relaxant Chiral Chemical

Categories Cutting Cycle Steroids
Brand Name: Jia Ye
Model Number: P-33
Certification: ISO9001
Place of Origin: China
MOQ: Negotiation
Price: Negotiation
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 1000kg a week
Delivery Time: 5-8 work days
Packaging Details: Disguised
CAS: 130-95-0
MF: C20H24N2O2
MW: 324.42
Purity: 99%
State: Solid
EINECS: 205-003-2
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    Quinine CAS 130-95-0 Raw Steroid Powders Antimalarial Muscle Relaxant Chiral Chemical

    Quinine CAS 130-95-0 Raw Steroid Powders Antimalarial Muscle Relaxant Chiral Chemical

    1. Description

    Quinine is a medication to treat malaria and babesiosis. This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available. While used for restless legs syndrome, it is not recommended for this purpose.

    It can be taken by mouth or used intravenously. Malaria that is resistant to quinine occurs in certain areas of the world. Some quantities are also used in tonic water and gives it its bitter taste. Common side effects include headache, ringing in the ears, trouble seeing, and sweating. More severe side effects include deafness, low blood platelets, and an irregular heartbeat. Use can make one more prone to sunburn. While it is unclear if use during pregnancy causes harm to the baby, use to treat malaria during pregnancy is still recommended. How it works is not entirely clear.

    Quinine was first isolated in 1820 from the bark of a cinchona tree. Bark extracts have been used to treat malaria since at least 1632. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. The wholesale price in the developing world is about US$1.70 to $3.40 per course of treatment. In the United States a course of treatment is more than $200.

    2. Uses

    As of 2006, it is no longer recommended by the WHO (World Health Organization) as a first-line treatment for malaria, and it should be used only when artemisinins are not available. Quinine is also used to treat lupus andarthritis.

    In the past, quinine was frequently prescribed in the US as an off-label treatment for nocturnal leg cramps, but this has become less prevalent due to a Food and Drug Administration statement warning against the practice.

    3. Available forms

    Quinine is a basic amine and is usually provided as a salt. Various existing preparations include the hydrochloride, dihydrochloride, sulfate, bisulfate and gluconate. In the United States, quinine sulfate is commercially available in 324-mg tablets under the brand name Qualaquin.

    All quinine salts may be given orally or intravenously (IV); quinine gluconate may also be given intramuscularly (IM) or rectally (PR). The main problem with the rectal route is that the dose can be expelled before it is completely absorbed; in practice, this is corrected by giving a further half dose. No injectable preparation of quinine is licensed in the US; quinidine is used instead.

    4. Adverse effects

    Quinine in some cases can lead to constipation, erectile dysfunction, diarrhea, and/or vivid dreams. The New York Times Magazine described a case presenting with fever, hypotension, and blood abnormalities mimicking septic shock, which was judged to be an adverse reaction to quinine.

    Quinine can also cause drug-induced immune thrombocytopenic purpura. Symptoms can be severe enough to require hospitalization and platelet transfusion, with several cases known to have resulted in death.

    mp173-175 °C(lit.)
    alpha-172 º (c=1, EtOH)
    storage temp.Refrigerator
    Water Solubilityslightly soluble
    SensitiveLight Sensitive
    CAS DataBase Reference130-95-0(CAS DataBase Reference)
    NIST Chemistry ReferenceQuinine(130-95-0)
    EPA Substance Registry SystemCinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)-(130-95-0)
    Hazard CodesXn,Xi
    Risk Statements36/37/38-42/43-22-20/22-20/21/22-36/38
    Safety Statements22-26-36/37-45-37/39-36-7
    WGK Germany3
    HS Code29392110
    Hazardous Substances Data130-95-0(Hazardous Substances Data)
    Chemical Propertieswhite to light yellow crystal powde
    UsagePrimary alkaloid of various species of Cinchona (Rubiaceae). Optical isomer of Quinidine. Antimalarial; muscle relaxant (skeletal)



    Appearancewhite or light yellow crystalline powder
    Specific Optical Rotation158°~168°
    Melting Point173ºC-178ºC
    Loss on Drying≤1.0%
    Residue on Ignition≤0.1%
    Heavy Metal<10ppm
    Other Cinchona Alkaloid<1.0%
    Quality Quinine CAS 130-95-0 Raw Steroid Powders Antimalarial Muscle Relaxant Chiral Chemical for sale
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