Sedative Drug Xylazine Hydrochloride / Xylazine HCl CAS 23076-35-9
for Muscle Relaxant
Product Name: XYLAZINE HYDROCHLORIDE
HCL;XYLAZINE HCL;XYLAZINE HYDROCHLORIDE
Chemical Properties: Off-White Solid
Usage: Xylazine HCl is α2 class of adrenergic receptor agonist. As
with other α2 agonists, adverse effects include bradycardia,
conduction disturbances, and myocardial depression. It is a
clonidine analoque. It acts on presynaptic and postsynaptic
receptors of t
Usage: Xylazine is used as a sedative, analgesic, muscle relaxant.
Xylazine is an analogue of clonidine and an agonist at the α2 class
of adrenergic receptor. It is used forsedation, anesthesia, muscle
relaxation, and analgesia in animals such as horses, cattle and
other non-human mammals.Veterinarians also use xylazine as an
emetic, especially in cats.
In veterinary anesthesia, xylazine is often used in combination. It
is sold under many brand names worldwide, most notably the Bayer
brand name Rompun.It is also marketed as Anased, Sedazine, and
Chanazine. The drug interactions vary with different animals.
Xylazine is often used as a sedative, muscle relaxant, and
analgesic.It is frequently used in the treatment of
tetanus.Xylazine is very similar to drugs such as phenothiazine,
tricyclic antidepressants, and clonidine.As an anesthetic, it is
typically used in conjunction with ketamine.
Xylazine appears to reduce sensitivity to insulin and glucose
uptake in humans.Yohimbine has been used to decrease glucose levels
to a healthy level.In clinical settings, Yohimbine can reverse the
adverse effects of xylazine if administered intravenously at a
dosage of 0.5 mL / 20 pounds shortly after xylazine administration.
Xylazine HCl Pharmacology
(1)Xylazine HCl Injection (xylazine), a non-narcotic compound, is a
sedative and analgesic as well as muscle relaxant. Its sedative and
analgesic activity is related to central nervous system depression.
Its muscle relaxant effect is based on inhibition of the
intraneural transmission of impulses in the central nervous system.
The principal pharmacological activities develop within 10 to 15
minutes after intramuscular injection in horses and Cervidae, and
within 3 to 5 minutes following intravenous administration in
(2)A sleeplike state, the depth of which is dose-dependent, is
usually maintained for 1 to 2 hours, while analgesia lasts from 15
to 30 minutes. The centrally-acting muscle relaxant effect causes
relaxation of the skeletal musculature, complementing sedation and
(3)In horses and Cervidae under the influence of Xylazine HCl
Injection (xylazine), the respiratory rate is reduced as in natural
sleep. Following treatment with Xylazine HCl Injection (xylazine),
the heart rate is decreased and a transient change in the
conductivity of the cardiac muscle may occur, as evidenced by a
partial atrioventricular block. This resembles the atrioventricular
block often observed in normal horses.1,2,3,4 Partial A-V block may
occasionally occur following intramuscular injection of Xylazine
HCl Injection (xylazine). When given intravenously in horses, the
incidence of partial A-V block is higher. Intravenous
administration causes a transient rise in blood pressure in horses,
followed by a slight decrease.
Xylazine Hydrochloride COA
|Items of analysis||Specification||Results|
|Appearance||White to almost white crystalline hygroscopic powder||White crystalline hygroscopic powder|
|Identification||A: IR absorption B: Thin-layer chromatographic identification test||Conforms|
|Loss of drying||Should conform to the standard||Conform|
|Melting range||NMT 1.0%||0.35%|
|Heavy metals||164 ºC -168 ºC||165.4-166.5ºC|
|Acidity or alkalinity:||NMT 20ppm||<20ppm|
|Residue on ignition||NMT 0.1%||0.05%|
|Chromatographic||Total impurities: NMT2.0%||Conforms|
|Solution clarity||Meet the requirement(CP Standard)||Conforms|
|Assay||Not less than 98.0% and not more than 102.0%||99.47%|
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